Publication Date: 2005-12-05
Edited by Ronald T. Borchardt, Edward H. Kerns, Christopher A. Lipinski, Dhiren R. Thakker, and Binghe Wang
Volume 1 of the AAPS Press series, Biotechnology: Pharmaceutical Aspects. Based on a 2003 AAPS workshop of the same name, Pharmaceutical Profiling in Drug Discovery for Lead Selection emphasizes the importance of accuracy in the prediction, measurement, and application of physiochemical and ADME properties, not only to guarantee successful lead selection in "hit-to-lead" research but also to avoid the common pitfalls that arise when property information is lacking. Its contributors include highly experienced leaders from both industry and academia, with specialization in advanced methods for in silico, physiochemical, permeability, in vitro, and ADME, as well as in medicinal chemistry applications on pharmaceutical property information.
Supporting Information and Data
Table of Contents
Question & Answer/Panel Discussion Transcripts
Session I: In Silico Tools
Session II: Physicochemical Methods
Session III: Permeability
Session IV: ADME
Session V: Application of Property Information to Lead Selection
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