Publication Date: 2011-08-03
Edited by Uday B. Kompella and Henry F. Edelhauser
Drug Product Development for the Back of the Eye was written by top investigators in respective areas and addresses methods of tissue isolation and drug analysis, noninvasive approaches, and nanotechnology-based products, as well as approaches to assess and model pharmacokinetics of the eye noninvasively and comprehensive coverage of transscleral drug delivery. This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include:
- solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms;
- refillable and microneedle devices;
- intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery;
- physical methods including iontophoresis for drug delivery;
- rational selection of routes of administration and delivery systems;
- noninvasive and continuous drug monitoring;
- clinical endpoints and regulatory path to drug product development;
- emerging and existing drugs and drug targets.
Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.
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